Last updated: Oct 6, 2021

SPRAVATO® is a prescription medicine, used along with an antidepressant taken by mouth, for treatment-resistant depression (TRD) in adults.

Treatment-Resistant Depression

Treatment-resistant depression is diagnosed in adults who were struggling with major depressive disorder and had not responded adequately to at least two different antidepressants of adequate dose and duration in the current depressive episode.

Treatment with SPRAVATO® 

SPRAVATO® is taken along with an oral antidepressant. You will administer SPRAVATO® nasal spray yourself under the supervision of a provider at Redefine Healthcare. SPRAVATO® sessions are twice a week for the first four weeks, and then once a week after the first four weeks. After this, SPRAVATO® is usually taken either once a week or once every two weeks, but can vary depending on the response. 

Advantages of SPRAVATO®

  • Alternative to ketamine infusion: IV Ketamine infusions have been shown in multiple large randomized controlled clinical trials to be safe and effective as a treatment for depression. However, some patients prefer not to have an IV infusion. Spravato provides an alternative, FDA-approved ketamine based treatment for depression.
  • Medical supervision: During your SPRAVATO™ treatment regimen, your doctor will work closely with you to ensure your well-being. You will receive each dosage at the office.
  • New option for treatment-resistant depression: SPRAVATO™ is one of the first new types of depression medication in decades. If you don’t have success with other depression medicines, SPRAVATO™ may be an alternative for you.

Today’s most commonly used oral antidepressants are thought to treat depression by increasing levels of neurotransmitters (serotonin, norepinephrine and dopamine) in areas of the brain that affect mood.  SPRAVATO® works differently in that it targets the N-methyl-D-aspartate (NMDA) receptor and is believed to work differently than currently available oral antidepressants.

Find Out If You’re a Candidate

If you’ve struggled with depression and tried two or more antidepressants in your current episode without adequate relief, talk to your provider at Redefine Healthcare to see if SPRAVATO® may be an option for you.

SPRAVATO® is not for use as a medicine to prevent or relieve pain (anesthetic). It is not known if SPRAVATO® is safe or effective as an anesthetic medicine.

It is not known if SPRAVATO® is safe and effective for use in preventing suicide or in reducing suicidal thoughts or actions. SPRAVATO® is not for use in place of hospitalization if your healthcare provider determines that hospitalization is needed, even if improvement is experienced after the first dose of SPRAVATO®. It is not known if SPRAVATO® is safe and effective in children.

This page was published on Sep 27, 2021, modified on Oct 6, 2021 by Dr. Freeman (Pain Management Specialist) of Redefine Healthcare
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